2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140297
    Carboxyrhodamine 110-PEG4-DBCO
    Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Carboxyrhodamine 110-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Carboxyrhodamine 110-PEG4-DBCO
  • HY-130192
    Cbz-NH-PEG8-C2-acid 1334177-87-5
    Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG8-C2-acid
  • HY-138736
    Propargyl-PEG5-Br 1287660-83-6
    Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-Br
  • HY-133191
    Bis-propargyl-PEG2 126422-57-9
    Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG2
  • HY-132080
    Bis-PEG8-t-butyl ester
    Bis-PEG8-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG8-t-butyl ester
  • HY-138389
    THP-PEG13-OH
    THP-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG13-OH
  • HY-140670
    m-PEG-acrylate (MW 2000)
    m-PEG-acrylate (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-acrylate (MW 2000)
  • HY-141030
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3 2107273-38-9
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3
  • HY-134755
    Bromo-PEG9-Boc
    Bromo-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG9-Boc
  • HY-141345
    S-acetyl-PEG2-Boc 1820641-93-7
    S-acetyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG2-Boc
  • HY-140493
    Biotin-PEG12-acid 1621423-14-0
    Biotin-PEG12-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG12-acid
  • HY-132010
    Benzyl-PEG8-azide
    Benzyl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG8-azide
  • HY-130446
    m-PEG9-NHS ester 1316189-13-5
    m-PEG9-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG9-NHS ester
  • HY-141314
    m-PEG4-C6-phosphonic acid ethyl ester 2028281-89-0
    m-PEG4-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-C6-phosphonic acid ethyl ester
  • HY-141182
    TCO-C3-PEG3-C3-amine 2028288-77-7
    TCO-C3-PEG3-C3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-C3-PEG3-C3-amine
  • HY-140841
    APN-C3-PEG4-azide 2183440-32-4 98.56%
    APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    APN-C3-PEG4-azide
  • HY-W096143
    NH2-PEG3 hydrochloride 92505-84-5
    NH2-PEG3 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3 hydrochloride
  • HY-141202
    Hydroxy-PEG5-Boc 850090-09-4
    Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG5-Boc
  • HY-140553
    N-Boc-N-bis-PEG5 2093154-02-8
    N-Boc-N-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-N-bis-PEG5
  • HY-135823
    Propargyl-PEG12-bromide 2410937-34-5
    Propargyl-PEG12-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG12-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG12-bromide
PROTAC Linkers Isoform Comparison

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